Genome Integrity and Instability

The research activity of the research group has as a main objective to study of the mechanism(s) that are responsible for the origin and maintenance of mammalian genome integrity. We reach our main goal through a multidisciplinary approach, combining computational analysis and whole-genome comparisons with cutting-edge experimental technologies in both somatic and meiotic cells. More specifically, the group is currently working in the following research lines: 1. Investigate the conservation and functionality of the high-structural organization of mammalian genomes, both in the somatic and the germ line. 2. Analysis of the signalling pathway that controls the progression of meiotic recombination in mammalian meiocytes. 3. Identification of the role of the DNA damage response machinery in the DSB repair occurring during the meiotic prophase. 4. Study how the DNA damage response mechanism controls the oocyte pool in mammals. 5. Identification of non-annotated genes in the mammalian genome required to complete meiosis. 6. Identification of the genetic basis of reproductive isolation and barriers of gene flow in mammalian natural populations. 7. Development of a cell line repository of endangered mammalian species. 8. Implementation of integrative bioinformatics and informatic tools for the analysis of the conservation and function of vertebrate genomes. 9. Study the impact of COVID-19 on fertility. More information: https://ibb.uab.cat/wp-content/themes/viral/modules/ibb_membres/view_grup.php?CodiGrup=27