Synthesis and biological study of substituted 3-carboethoxy-4-aminoquinolines

Resume: It synthesizes a series of 3-carboethoxy-4-aminoquinolines substituted in position 6 and another series substituted in position 7. The study by molecular modeling makes it possible to determine the molecular descriptors that appear to be important in biological activity. Most of the compounds were cytotoxicly innocuous at the concentration of 50mg/ml, which makes them attractive for further studies.